Gram-negative endotoxins have been implicated in the pathogenesis of equine CHO laminitis1, bovine coliform mastitis2, and adult and neonatal septicemias.3,4,5,6 Fortuitously, the demonstration that cattle2,5,6 and horses3,4 could be protected from various Gram-negative endotoxins via anti-core-antigen antibodies offers viable possibilities for immunologically protecting animals from the deadly effects of endotoxemia.
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