Normal specific pathogen free feeder pigs were actively immunized with Re-17 mutant Salmonella typhimurium bacterin-toxoid and their clinical responses to intravenously administered Salmonella choleraesuis endotoxin statistically compared to responses of control (non-vaccinated) pigs.
Horse owners know all too well the health problems that can happen quickly without notice. They also know its impossible to prevent conditions such as blocked intestine or a retained placenta.
Twenty normal ponies were vaccinated twice with a Salmonella typhimurium bacterin-toxoid at 14-day intervals. Simultaneously, 20 normal control ponies each received two injections of dialuminum trioxide/saline placebo at 14-day intervals.
Normal ponies were passively immunized with antiserum. The antiserum contained an endotoxin-specific IgG(t) antibody titer of > 1:16000 and a total IgG antibody level of > 3000 mg/dl, which was harvested from horses hyperimmunized with a Salmonella typhimurium bacterin-toxoid.
The purpose was to determine if immunization with an E. coli Bacterin-Toxoid J-5 Mutant in lactating cattle produced a significant change in milk production compared to saline control.
Determine the effects of vaccinations with ENDOVAC – BOVI of lactating dairy cows.
Core antigen vaccine technology has been available for the prevention of coliform mastitis for over ten years.
What is gram-negative ENDOTOXEMIA?
Gram-negative endotoxins have been implicated in the pathogenesis of equine CHO laminitis1, bovine coliform mastitis2, and adult and neonatal septicemias.3,4,5,6 Fortuitously, the demonstration that cattle2,5,6 and horses3,4 could be protected from various Gram-negative endotoxins via anti-core-antigen antibodies offers viable possibilities for immunologically protecting animals from the deadly effects of endotoxemia.
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