Twenty normal ponies were vaccinated twice with a Salmonella typhimurium bacterin-toxoid at 14-day intervals. Simultaneously, 20 normal control ponies each received two injections of dialuminum trioxide/saline placebo at 14-day intervals.
Normal ponies were passively immunized with antiserum. The antiserum contained an endotoxin-specific IgG(t) antibody titer of > 1:16000 and a total IgG antibody level of > 3000 mg/dl, which was harvested from horses hyperimmunized with a Salmonella typhimurium bacterin-toxoid.
The purpose was to determine if immunization with an E. coli Bacterin-Toxoid J-5 Mutant in lactating cattle produced a significant change in milk production compared to saline control.
Determine the effects of vaccinations with ENDOVAC – BOVI of lactating dairy cows.
Core antigen vaccine technology has been available for the prevention of coliform mastitis for over ten years.
What is gram-negative ENDOTOXEMIA?
Gram-negative endotoxins have been implicated in the pathogenesis of equine CHO laminitis1, bovine coliform mastitis2, and adult and neonatal septicemias.3,4,5,6 Fortuitously, the demonstration that cattle2,5,6 and horses3,4 could be protected from various Gram-negative endotoxins via anti-core-antigen antibodies offers viable possibilities for immunologically protecting animals from the deadly effects of endotoxemia.
Mastitis occurs in 10% to 12% of all lactating cows inthe United States, with 30% to
40% of mastitis cows have inflammation due to Escherichia coli. Mastitis costs U.S. dairy
producers more than $1 billion annually.
Endotoxemias associated with bovine respiratory disease complex (BRDC) have been effectively controlled in lightweight Holstein feeder steers by Re-17 mutant Salmonella typhimurium bacterin-toxoid (ENDOVAC-Bovi® United States Department of Agriculture-licensed S. Typhimurium Bacterin-Toxoid: IMMVAC, Inc., Columbia, MO).1
In this study, 149 lightweight feeder steers were randomly divided into three groups. All steers were administered appropriate viral vaccines upon arrival and 10 days following arrival.
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